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编 号:F416329
分子式:C21H30O3
分子量:330.46
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM. Deoxycorticosterone could acts as an immune stimulator in fish.

体内研究:
Deoxycorticosterone (0.08 mg/kg,腹腔注射,单剂量) 可增加脾脏和鳃中 C 型溶菌酶和载脂蛋白 A1 的表达,表明其在欧亚鲈鱼内与发挥免疫刺激作用有关。Animal Model:Eurasian perch
Dosage:0.08 mg/kg
Administration:i.p.
Result:Upregulated mRNA expression of genes coding for 11β-HSD2 and MR in spleen.Unregulated expressions of C type lysozyme mRNA in spleen and Apo A1 mRNA in spleen and gills.

体外研究:
Deoxycorticosterone 增强 rtMR 转录活性,参与调解精液的流动性。
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