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编 号:F415996
分子式:C69H103N19O14
分子量:1422.68
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生物活性:
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine.

体内研究:
Granuliberin R (0.1 mg/mL, 1 μg/mL, and 10 ng/mL; injection; single dose for 60 s) interfere in the proliferation of oral keratinocytes and the activity of connective tissue cells when treatment is conducted into rats mandibular gingiva in the vicinity of the right mental foramen.

体外研究:
Granuliberin R (10 μg/mL) does not alter the release of catecholamines and adenine nucleotides from cultured adrenal chromaffin cells, while the Mastoparan (10 μg/mL) increases both of them.
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