产品
编 号：F415651
分子式：C10H24N4O4S
分子量：296.39
分子式：C10H24N4O4S
分子量：296.39
产品类型
规格
价格
是否有货
100mg
400
In-stock
500mg
询价
询价
结构图
CAS No: 645-43-2
产品详情
生物活性：
Guanethidine sulfate (Guanethidine monosulfate) ia an antihypertensive agents. Guanethidine is also an adrenergic neurone blocking agent, enters noradrenergic nerve terminals by the neuronal amine carrier.
体内研究：
Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes.Animal Model:Male Wistar rats (approximately 200 g)
Dosage:5 mg/kg or 40 mg/kg
Administration:Intraperitoneal injection; daily; for 4, 8, 14, or 28 days
Result:Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.
Guanethidine sulfate (Guanethidine monosulfate) ia an antihypertensive agents. Guanethidine is also an adrenergic neurone blocking agent, enters noradrenergic nerve terminals by the neuronal amine carrier.
体内研究：
Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes.Animal Model:Male Wistar rats (approximately 200 g)
Dosage:5 mg/kg or 40 mg/kg
Administration:Intraperitoneal injection; daily; for 4, 8, 14, or 28 days
Result:Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg.
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