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编 号:F415604
分子式:C15H23NO3
分子量:265.35
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生物活性:
Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.

体内研究:
Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade together with peak plasma drug levels within the normal clinical range.Animal Model:Male rats (230 to 300 g body wt) of the Wistar strain
Dosage:200 mg/kg
Administration:Administered orally; daily for 3 weeks
Result:This dosage produced effective beta-blockade.

体外研究:
Oxprenolol is lipophilic.Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin.
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