产品
编 号:F046733
分子式:C49H66N12O6S
分子量:951.19
产品类型
结构图
CAS No: 115150-59-9
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产品详情
生物活性:
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy.
体外研究:
Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.Antagonist G activates JNK1 in SCLC cells.Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.