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编 号：F414793
分子式：C12H17N3O4S
分子量：299.35
分子式：C12H17N3O4S
分子量：299.35
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CAS No: 64221-86-9
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生物活性：
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
体内研究：
Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single).50Drug and dose(mg/kg)Cmax(mg/liter)Tmax(min)AUCtot(mg ? min/liter)Vz/F(ml/kg)Vss/F (ml/kg)CL/F(ml/min/kg)t1/2(min)MRT(min)
Imipenem
815 (7.1)21 (11)1,470 (777)648 (330)721 (343)6.7 (3)67 (11)108 (12)
1634 (6)28 (18)2,857 (559)507 (140)543 (121)5.8 (1)60 (9.1)94 (10)3254 (11)18 (6.1)4,895 (635)516 (75)566 (83)6.6 (0.8)54 (6.5)86 (11)6469 (37)15 (9.5)6,037 (2,976)547 (274)617 (308)7.4 (3.6)43 (22)70 (35)
Animal Model:Neutropenic mouse model of biofilm lung infection
Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.
体内研究：
Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent.Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single).50Drug and dose(mg/kg)Cmax(mg/liter)Tmax(min)AUCtot(mg ? min/liter)Vz/F(ml/kg)Vss/F (ml/kg)CL/F(ml/min/kg)t1/2(min)MRT(min)
Imipenem
815 (7.1)21 (11)1,470 (777)648 (330)721 (343)6.7 (3)67 (11)108 (12)
1634 (6)28 (18)2,857 (559)507 (140)543 (121)5.8 (1)60 (9.1)94 (10)3254 (11)18 (6.1)4,895 (635)516 (75)566 (83)6.6 (0.8)54 (6.5)86 (11)6469 (37)15 (9.5)6,037 (2,976)547 (274)617 (308)7.4 (3.6)43 (22)70 (35)
Animal Model:Neutropenic mouse model of biofilm lung infection
Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
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