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编 号：F414775
分子式：C18H13Cl4N3O
分子量：429.13
分子式：C18H13Cl4N3O
分子量：429.13
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CAS No: 64211-45-6
产品详情
生物活性：
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
体内研究：
Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth.Animal Model:BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)
Dosage:50 mg/kg/day
Administration:IP; for 12 days
Result:Significantly restrained CRC cell growth and showed no obvious side effects.
体外研究：
Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth.Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton.Antifungal Activities of Oxiconazole.Candidaalbicans Candidaglabrata Candidaparapsilosis Aspergillusfumigatus Aspergillusflavus Trichophytonmentagrophytes Trichophytonrubrum
Oxiconazole0.03 μg/mL0.01 μg/mL0.008 μg/mL2 μg/mL2 μg/mL2 μg/mL2 μg/mL
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
体内研究：
Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth.Animal Model:BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)
Dosage:50 mg/kg/day
Administration:IP; for 12 days
Result:Significantly restrained CRC cell growth and showed no obvious side effects.
体外研究：
Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth.Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton.Antifungal Activities of Oxiconazole.Candidaalbicans Candidaglabrata Candidaparapsilosis Aspergillusfumigatus Aspergillusflavus Trichophytonmentagrophytes Trichophytonrubrum
Oxiconazole0.03 μg/mL0.01 μg/mL0.008 μg/mL2 μg/mL2 μg/mL2 μg/mL2 μg/mL
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