产品
编 号:F414754
分子式:C12H14O4
分子量:222.24
产品类型
结构图
CAS No: 64206-54-8
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生物活性:
Valeryl salicylate is a potent and irreversible cyclooxygenase-1 (COX-1) inhibitor. Valeryl salicylate shows anti-inflammatory effect.
体内研究:
Valeryl salicylate (3, 10, 30 mg/kg; i.p.) 对花生四烯酸 (HY-109590) 引起的耳水肿和角叉菜胶 (HY-125474) 引起的爪水肿具有抗炎作用。Animal Model:25-30g, Swiss male mice (arachidonic acid induces Ear oedema)
Dosage:1.5, 4.5, 15, 45 μg per ear
Administration:
Result:Showed the anti-inflammatory effect of topical administration and resulted in significant inhibition of the ear oedema of28, 36, 40, and 58% at 1.5, 4.5, 15, 45 μg per ear.
Animal Model:25-30g, Swiss male mice (Carrageenan-induced paw oedema)
Dosage:3, 10, 30 mg/kg
Administration:I.p.
Result:Promoted a significant inhibition of 43.3, 53.3 and 66.6% at 3, 10, 30 mg/kg, respectively.