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编 号：F414466
分子式：C20H22O2
分子量：294.39
分子式：C20H22O2
分子量：294.39
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CAS No: 64095-60-9
产品详情
生物活性：
Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases.
体内研究：
Longistyline A (10 μg dissolved in 50 μL PBS buffer; apply to the wound; for 30 min) improves wound healing, decreases MRSA bacterial survivals in the lesions and reduces inflammatory reaction in MRSA infected mice.Animal Model:Female wound healing BALB/c mice with MRSA infection
Dosage:10 μg
Administration:Apply to the wound; 10 μg dissolved in 50 μL PBS buffer; 5 min after infection for 30 min
Result:Showed a wound healing efficiency and significantly alleviated weight loss induced by MRSA infection. Reduced gram-positive microorganisms in vivo with a better effect than vancomycin. Reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α and IL-6 in serum.
体外研究：
Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells.Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation.Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL.Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50 value of 8.61 μg/mL.
Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases.
体内研究：
Longistyline A (10 μg dissolved in 50 μL PBS buffer; apply to the wound; for 30 min) improves wound healing, decreases MRSA bacterial survivals in the lesions and reduces inflammatory reaction in MRSA infected mice.Animal Model:Female wound healing BALB/c mice with MRSA infection
Dosage:10 μg
Administration:Apply to the wound; 10 μg dissolved in 50 μL PBS buffer; 5 min after infection for 30 min
Result:Showed a wound healing efficiency and significantly alleviated weight loss induced by MRSA infection. Reduced gram-positive microorganisms in vivo with a better effect than vancomycin. Reduced accumulation of immune cells at the injury site and alleviated induction of TNF-α and IL-6 in serum.
体外研究：
Longistyline A (4-16 μM/L; 48 h) reduces the corticosterone-induced neurotoxicity in PC12 cells.Longistyline A can function as a membrane-targeting antibacterial agent by disturbing bacterial membrane potential and increasing the permeation.Longistyline A (0-100 μg/mL) shows significant antimicrobial activity against tested Gram-positive bacteria, such as B.cereus CMCC63302 with MIC values of 25 μg/mL, S.aureus CMCC26003 with MIC values of 1.56 μg/mL, and both two strains of MRSA (JCSC4744 and JCSC4469) with MIC values of 1.56 μg/mL.Longistyline A (24 h) shows cytotoxicity towards murine RAW264.7 cells with an IC50 value of 8.61 μg/mL.
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