产品
编 号：F413090
分子式：C29H39N5O7
分子量：569.65
分子式：C29H39N5O7
分子量：569.65
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 63631-40-3
产品详情
生物活性：
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) is a water soluble Opioid Receptor peptide agonist.
体内研究：
BW-180C ([D-Ala2, D-Leu5]-Enkephalin)protects against I-R injury in hepatocytes, but not in the sinusoidal endothelial cells of the liver in rats. GPT levels are significantly lower in the BW-180C group as compared to those of the Control group, but the serum levels of HA are not different between the two groups. The concentrations of MDA of the liver tissue are significantly lower in the BW-180C group than in the Control group. BW-180C (DADLE)-induced analgesia is mediated by the stimulation of both mu- and delta-opioid receptors.Animal Model:Male Wistar rats weighing 200 to 250 g
Dosage:5 mg/kg
Administration:Administered intravenously into the inferior vena cava
Result:After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.
Animal Model:Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)
Dosage:5 mg/kg
Administration:Injected intraperitoneally 15 min prior to I/R
Result:The serum levels of AST and ALT in the serum DADLE group were significantly lower.
体外研究：
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) significantly inhibits cellular transcription in SH-SY5Y cells without causing cell injury. Following recovery for 72 h without BW-180C in primary neurons, the transcriptional activity fully resumes.
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) is a water soluble Opioid Receptor peptide agonist.
体内研究：
BW-180C ([D-Ala2, D-Leu5]-Enkephalin)protects against I-R injury in hepatocytes, but not in the sinusoidal endothelial cells of the liver in rats. GPT levels are significantly lower in the BW-180C group as compared to those of the Control group, but the serum levels of HA are not different between the two groups. The concentrations of MDA of the liver tissue are significantly lower in the BW-180C group than in the Control group. BW-180C (DADLE)-induced analgesia is mediated by the stimulation of both mu- and delta-opioid receptors.Animal Model:Male Wistar rats weighing 200 to 250 g
Dosage:5 mg/kg
Administration:Administered intravenously into the inferior vena cava
Result:After 120 min of reperfusion, the serum GPT levels were significantly lower in the DADLE group than in the Control group.
Animal Model:Male C57BL/6 mice (age, 35-42 days; weight, 18-22 g; 6 mice in each group)
Dosage:5 mg/kg
Administration:Injected intraperitoneally 15 min prior to I/R
Result:The serum levels of AST and ALT in the serum DADLE group were significantly lower.
体外研究：
BW-180C ([D-Ala2, D-Leu5]-Enkephalin) significantly inhibits cellular transcription in SH-SY5Y cells without causing cell injury. Following recovery for 72 h without BW-180C in primary neurons, the transcriptional activity fully resumes.
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