产品
编 号：F046427
分子式：C5H7N3O4
分子量：173.13
分子式：C5H7N3O4
分子量：173.13
产品类型
规格
价格
是否有货
1mg
450
In-stock
5mg
1020
In-stock
10mg
1500
In-stock
结构图
CAS No: 115-02-6
产品详情
生物活性：
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection.
体内研究：
Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats.Animal Model:Wistar rats
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month
Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
体外研究：
Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.?Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection.
体内研究：
Azaserine (5 mg/kg; i.p. once or twice a week for 6 months) induces tumor in rats.Animal Model:Wistar rats
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg once or twice a week for 6 month
Result:After 1 year most pancreases from treated rats were diffusely abnormal and contained many hyperplastic nodules and adenomas and more than rats one-quarter showed pancreatic adenocarcinoma.
体外研究：
Azaserine (100 μg/mL; 6 h) causes some specific types of morphological changes of the sensitive organisms such as the characteristic elongation of Candida albicans cells.?Azaserine (0-10 μM) inhibits the growth of E. coli strains with MIC values of 12.11, 51.9, 69.2 and 69.2 μg/mL for UTH 4, UTH 7036, UTH 7048 and UTH 7049.
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