产品
编 号：F412445
分子式：C21H27F2N5O2
分子量：419.47
分子式：C21H27F2N5O2
分子量：419.47
产品类型
规格
价格
是否有货
结构图
CAS No: 634193-54-7
产品详情
生物活性：
L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.
体内研究：
L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.Animal Model:Adult male Sprague-Dawley rats injected with crotaline to induce pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy
Dosage:0.25 μg/kg/day, 0.4 μg/kg/day or 1 μg/kg/day
Administration:Intraperitoneal injection; daily; for 3 weeks
Result:Reduced right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.
体外研究：
L-902688 (1 μM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression.
L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.
体内研究：
L-902688 (0.25-1 μg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.Animal Model:Adult male Sprague-Dawley rats injected with crotaline to induce pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy
Dosage:0.25 μg/kg/day, 0.4 μg/kg/day or 1 μg/kg/day
Administration:Intraperitoneal injection; daily; for 3 weeks
Result:Reduced right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.
体外研究：
L-902688 (1 μM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备