产品
编 号：F412406
分子式：C53H87NO19
分子量：1042.25
分子式：C53H87NO19
分子量：1042.25
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 63409-12-1
产品详情
生物活性：
Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation.
体内研究：
Tylvalosin tartrate (160 mg/kg; po; 7 d) 可以减轻 PRRSV 灭活疫苗免疫过程中猪的应激状态并改善猪的健康情况。Animal Model:PRRSV-free commercial breed piglets
Dosage:800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
Administration:po; 7-14 days
Result:Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
体外研究：
Tylvalosin (10 μg/mL; 0.5, 1 h) 增加猪中性粒细胞中的 Caspase-3 裂解，导致细胞凋亡期间 DNA 断裂。Tylvalosin (0.1-10 μg/mL; 0.5 h) 促进巨噬细胞对猪中性粒细胞的胞吞作用，而不改变吞噬作用。
Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation.
体内研究：
Tylvalosin tartrate (160 mg/kg; po; 7 d) 可以减轻 PRRSV 灭活疫苗免疫过程中猪的应激状态并改善猪的健康情况。Animal Model:PRRSV-free commercial breed piglets
Dosage:800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
Administration:po; 7-14 days
Result:Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
体外研究：
Tylvalosin (10 μg/mL; 0.5, 1 h) 增加猪中性粒细胞中的 Caspase-3 裂解，导致细胞凋亡期间 DNA 断裂。Tylvalosin (0.1-10 μg/mL; 0.5 h) 促进巨噬细胞对猪中性粒细胞的胞吞作用，而不改变吞噬作用。
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