生物活性: Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer.
体外研究: Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an ICPim-1/2 kinase inhibitor 1 相关抗体:Cell Cytotoxicity AssayCell Line:PC3 cells
Concentration:varying concentrations
Incubation Time:48 h
Result:Inhibited PC3 cells with an IC