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编 号：F410800
分子式：C16H23ClN2O3
分子量：326.82
分子式：C16H23ClN2O3
分子量：326.82
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CAS No: 62929-91-3
产品详情
生物活性：
Procaterol hydrochloride is a selective intermediate-acting β2 adrenoreceptor agonist with an EC50 of 12.9 μM. Procaterol hydrochloride can inhibit inflammation both in vivo and in vitro.
体内研究：
Procaterol significantly increases conditioned stimulus (CS)-evoked freezing levels. Propranolol-mediated blockade of β-adrenergic receptors (β-ARs) significantly reduces behavioral expression of Pavlovian threat conditioning (PTC), whereas systemic activation of β2-ARs using Procaterol enhances it.Procaterol hydrochloride is freshly dissolved in 0.9% sterile saline immediately prior to injections.Animal Model:Adult male Sprague-Dawley rats, weighing 250-275?g (~60-70 days old)
Dosage:300?μg/kg
Administration:Intraperitoneal (IP) injection
Result:Systemic injection of the specific β2-AR agonist procaterol (300?μg/kg) enhanced CS-elicited freezing during the expression test, with no effect during a drug free test.
体外研究：
Procaterol treat inflammation through inhibiting oxidative stress in vitro. Procaterol (25-200 nM) increases the viability of 16HBE cells.
Procaterol hydrochloride is a selective intermediate-acting β2 adrenoreceptor agonist with an EC50 of 12.9 μM. Procaterol hydrochloride can inhibit inflammation both in vivo and in vitro.
体内研究：
Procaterol significantly increases conditioned stimulus (CS)-evoked freezing levels. Propranolol-mediated blockade of β-adrenergic receptors (β-ARs) significantly reduces behavioral expression of Pavlovian threat conditioning (PTC), whereas systemic activation of β2-ARs using Procaterol enhances it.Procaterol hydrochloride is freshly dissolved in 0.9% sterile saline immediately prior to injections.Animal Model:Adult male Sprague-Dawley rats, weighing 250-275?g (~60-70 days old)
Dosage:300?μg/kg
Administration:Intraperitoneal (IP) injection
Result:Systemic injection of the specific β2-AR agonist procaterol (300?μg/kg) enhanced CS-elicited freezing during the expression test, with no effect during a drug free test.
体外研究：
Procaterol treat inflammation through inhibiting oxidative stress in vitro. Procaterol (25-200 nM) increases the viability of 16HBE cells.
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