产品
编 号:F410456
分子式:C8H9HgNO2
分子量:351.75
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10mM*1mL in DMSO
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50mg
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100mg
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生物活性:
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor.

体外研究:
p-Aminophenylmercuric acetate (APMA) (0-30 μM;20 min) 减少了大鼠脑匀浆中二氢吗啡结合位点的数量,增加了激动剂对结合钠抑制作用的敏感性。p-Aminophenylmercuric acetate (0.5 mM;30 min) 激活基质金属蛋白酶 2 和 9。
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