产品
编 号:F046095
分子式:C31H43N3Na10O49S8
分子量:1728.08
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1mg
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5mg
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10mg
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25mg
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50mg
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生物活性:
Fondaparinux sodium is an antithrombin-dependent factor Xa inhibitor.

体内研究:
Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period. The drug does not affect prothrombin time or activated partial thromboplastin time, nor does it affect platelet function or aggregation.

体外研究:
Fondaparinux sodium is the first agent of a new class of anticoagulants that selectively target factor Xa. For Fondaparinux, its IC50 values (anti-Xa IU/ml) are 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs).
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