产品
编 号：F409091
分子式：C30H46O3
分子量：454.68
分子式：C30H46O3
分子量：454.68
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
320
In-stock
10mg
400
In-stock
25mg
560
In-stock
50mg
712
In-stock
100mg
1080
In-stock
结构图
CAS No: 6246-46-4
产品详情
生物活性：
Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity.
体内研究：
Ursolic acid (5-20 mg/kg，口服，每天两次，持续 30 天) 可保护成年雄性白化大鼠免受乙醇介导的实验性肝损伤。Animal Model:Adult male albino rats
Dosage:5-20 mg/kg
Administration:p.o., twice a day, 30 days
Result:Increased weight gain and food intake.Decreased AST and ALT activities and total and indirect bilirubin levels.Increased direct bilirubin and levels of non-enzymic antioxidants (GSH, ascorbic acid and a-tocopherol).Decreased lipid peroxidation.
体外研究：
Ursolic acid (12.5-50 μM, 48 h) 通过抑制 AKT/NF-κB 信号通路以剂量依赖性方式诱导 T24 人膀胱癌细胞凋亡。Ursolic acid (50 μM, 2-4 h) 可增加 B16F-10 黑色素瘤细胞中 p53 和 caspase-3 的表达并降低 bcl-2 基因表达。Ursolic acid (10-50 μM, 48 h) 抑制 B16F-10 黑色素瘤细胞中 TNF-α、IL-1β、IL-6 和 GM-CSF 的产生。Ursolic acid (50 μM, 2 h) 抑制 B16F-10 黑色素瘤细胞中的 NF-κB 亚基 (p65、p50 和 c-Rel) 以及 c-fos、ATF-2 和 CREB-1 的核转位。
Ursolic acid is a naturally occurring triterpenoid that has orally active. Ursolic acid induces the apoptosis of human cancer cells through multiple signaling pathways. Ursolic acid has anti-inflammatory and anticarcinogenic activity.
体内研究：
Ursolic acid (5-20 mg/kg，口服，每天两次，持续 30 天) 可保护成年雄性白化大鼠免受乙醇介导的实验性肝损伤。Animal Model:Adult male albino rats
Dosage:5-20 mg/kg
Administration:p.o., twice a day, 30 days
Result:Increased weight gain and food intake.Decreased AST and ALT activities and total and indirect bilirubin levels.Increased direct bilirubin and levels of non-enzymic antioxidants (GSH, ascorbic acid and a-tocopherol).Decreased lipid peroxidation.
体外研究：
Ursolic acid (12.5-50 μM, 48 h) 通过抑制 AKT/NF-κB 信号通路以剂量依赖性方式诱导 T24 人膀胱癌细胞凋亡。Ursolic acid (50 μM, 2-4 h) 可增加 B16F-10 黑色素瘤细胞中 p53 和 caspase-3 的表达并降低 bcl-2 基因表达。Ursolic acid (10-50 μM, 48 h) 抑制 B16F-10 黑色素瘤细胞中 TNF-α、IL-1β、IL-6 和 GM-CSF 的产生。Ursolic acid (50 μM, 2 h) 抑制 B16F-10 黑色素瘤细胞中的 NF-κB 亚基 (p65、p50 和 c-Rel) 以及 c-fos、ATF-2 和 CREB-1 的核转位。
产品资料
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