产品
编 号：F408672
分子式：C8H12ClNO2
分子量：189.64
分子式：C8H12ClNO2
分子量：189.64
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
168
In-stock
100mg
280
In-stock
500mg
520
In-stock
结构图
CAS No: 62-31-7
产品详情
生物活性：
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
体内研究：
Dopamine hydrochloride (50 mg/kg；腹腔注射；1-7 天) 强烈且选择性地抑制 VPF/VEGF 的血管透化和血管生成活性。Animal Model:Syngeneic C3Heb/FeJ mice with MOT ascites tumors
Dosage:50 mg/kg
Administration:I.p. injection; 7 days
Result:Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
体外研究：
血管通透性因子/血管内皮生长因子 (VPF/VEGF) 强烈刺激人脐静脉内皮细胞 (HUVEC) 增殖。VPF/VEGF 的刺激作用被 Dopamine hydrochloride (1 μM；24 h) 消除。
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
体内研究：
Dopamine hydrochloride (50 mg/kg；腹腔注射；1-7 天) 强烈且选择性地抑制 VPF/VEGF 的血管透化和血管生成活性。Animal Model:Syngeneic C3Heb/FeJ mice with MOT ascites tumors
Dosage:50 mg/kg
Administration:I.p. injection; 7 days
Result:Corresponding to ~5% of the median lethal dose (LD50) in mice) beginning at 24 hours after tumor-cell injection and continuing daily for 7 days.
体外研究：
血管通透性因子/血管内皮生长因子 (VPF/VEGF) 强烈刺激人脐静脉内皮细胞 (HUVEC) 增殖。VPF/VEGF 的刺激作用被 Dopamine hydrochloride (1 μM；24 h) 消除。
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