产品
编 号：F408579
分子式：C20H12N2O3
分子量：328.32
分子式：C20H12N2O3
分子量：328.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 622864-54-4
产品详情
生物活性：
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.
体外研究：
PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3.PD 407824 is selective for Chk1 and WEE1 over PKC and Cdk4 with IC50s of 3.4 μM and 3.75 μM, respectively.
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.
体外研究：
PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3.PD 407824 is selective for Chk1 and WEE1 over PKC and Cdk4 with IC50s of 3.4 μM and 3.75 μM, respectively.
产品资料
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