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编 号:F408420
分子式:C28H16ClF6N5O
分子量:587.9
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Tradipitant (VLY-686) is a neurokinin-1 (NK-1) antagonist.

体内研究:
Autoradiography experiments reveal that intravenously administered Tradipitant ([3H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands.

体外研究:
Results reveal that Tradipitant ([3H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal).
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