产品
编 号：F408395
分子式：C18H24ClNO
分子量：305.84
分子式：C18H24ClNO
分子量：305.84
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规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 62232-46-6
产品详情
生物活性：
Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.
体内研究：
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.Animal Model:Wistar male rats (230-270 g) are induced hypothermia by Reserpine
Dosage:20, 40, 80 mg/kg
Administration:A single i.p.
Result:Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
体外研究：
Bifemelane inhibits MAO-A in a dose-dependent manner, with Kis of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.Bifemelane inhibits MAO-B activities in a dose-dependent manner, with Kis of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease.
体内研究：
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.Animal Model:Wistar male rats (230-270 g) are induced hypothermia by Reserpine
Dosage:20, 40, 80 mg/kg
Administration:A single i.p.
Result:Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
体外研究：
Bifemelane inhibits MAO-A in a dose-dependent manner, with Kis of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.Bifemelane inhibits MAO-B activities in a dose-dependent manner, with Kis of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
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