产品
编 号：F408252
分子式：C33H62O6
分子量：554.84
分子式：C33H62O6
分子量：554.84
产品类型
规格
价格
是否有货
100mg
280
In-stock
结构图
CAS No: 621-71-6
产品详情
生物活性：
Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics.
体内研究：
Trisdecanoin (静脉注射; 1h, 4h) 在脂肪甘油三酯脂肪酶 (Atgl) 基因敲除 (KO) 的小鼠中具有促进 Atgl KO 小鼠心肌中的长链脂肪酸 (LCFA) 代谢，减少 Atgl KO 小鼠心脏中脂质积累以及改善 Atgl KO 小鼠左心室功能的作用。Trisdecanoin (1145 mg/kg/day; 口服; 2周) 在 Male Sprague-Dawley 大鼠模型中具有预防和抑制腹主动脉瘤发生以及减轻早期平滑肌细胞 (SMCs) 的凋亡和功能障碍的作用。Animal Model:Male Sprague-Dawley rats
Dosage:1145 mg/kg/day
Administration:Oral gavage (p.o.)
Result:There was no significant difference in the incidence of AAA between the control and ricaprylin groups (30.2% vs 24.0%). In contrast, the incidence of AAA in Trisdecanoin was significantly lower than in the control group (30.2% vs. 3.6%).The AAA rupture rates in control group and C8-TG group were 31.3% and 33.3%, respectively. There was no aneurysm rupture in Trisdecanoin group.The mean aortic diameter of Trisdecanoin group was significantly lower than that of control group..
Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics.
体内研究：
Trisdecanoin (静脉注射; 1h, 4h) 在脂肪甘油三酯脂肪酶 (Atgl) 基因敲除 (KO) 的小鼠中具有促进 Atgl KO 小鼠心肌中的长链脂肪酸 (LCFA) 代谢，减少 Atgl KO 小鼠心脏中脂质积累以及改善 Atgl KO 小鼠左心室功能的作用。Trisdecanoin (1145 mg/kg/day; 口服; 2周) 在 Male Sprague-Dawley 大鼠模型中具有预防和抑制腹主动脉瘤发生以及减轻早期平滑肌细胞 (SMCs) 的凋亡和功能障碍的作用。Animal Model:Male Sprague-Dawley rats
Dosage:1145 mg/kg/day
Administration:Oral gavage (p.o.)
Result:There was no significant difference in the incidence of AAA between the control and ricaprylin groups (30.2% vs 24.0%). In contrast, the incidence of AAA in Trisdecanoin was significantly lower than in the control group (30.2% vs. 3.6%).The AAA rupture rates in control group and C8-TG group were 31.3% and 33.3%, respectively. There was no aneurysm rupture in Trisdecanoin group.The mean aortic diameter of Trisdecanoin group was significantly lower than that of control group..
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