产品
编 号：F407794
分子式：C22H21N3O3
分子量：375.42
分子式：C22H21N3O3
分子量：375.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
询价
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5mg
询价
询价
10mg
询价
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50mg
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询价
结构图
CAS No: 620175-39-5
产品详情
生物活性：
AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ?0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith.
体内研究：
AFN-1252 (0.03-3 mg/kg；口服灌胃；单剂量) 对败血症小鼠模型有效，单次口服剂量 1 mg/kg 可获得 100% 存活率。Animal Model:Female 5- to 6-week-old CD-1 mice (18 to 22 g) with S. aureus Smith bacterial inoculum
Dosage:0.03, 0.1, 0.3, 1, 3 mg/kg
Administration:Oral gavage; single dose
Result:Was efficacious in a mouse model of septicemia, with 100% survival obtained with a single oral dose of 1 mg/kg. The calculated ED50s (95% confidence limits) were 0.15 (0.11 to 0.21) mg/kg.
体外研究：
AFN-1252 对临床分离的金黄色葡萄球菌 (MIC90=0.015 μg/ml) 和凝固酶阴性葡萄球菌 (MIC90=0.12 μg/ml) 非常有效
AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ?0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith.
体内研究：
AFN-1252 (0.03-3 mg/kg；口服灌胃；单剂量) 对败血症小鼠模型有效，单次口服剂量 1 mg/kg 可获得 100% 存活率。Animal Model:Female 5- to 6-week-old CD-1 mice (18 to 22 g) with S. aureus Smith bacterial inoculum
Dosage:0.03, 0.1, 0.3, 1, 3 mg/kg
Administration:Oral gavage; single dose
Result:Was efficacious in a mouse model of septicemia, with 100% survival obtained with a single oral dose of 1 mg/kg. The calculated ED50s (95% confidence limits) were 0.15 (0.11 to 0.21) mg/kg.
体外研究：
AFN-1252 对临床分离的金黄色葡萄球菌 (MIC90=0.015 μg/ml) 和凝固酶阴性葡萄球菌 (MIC90=0.12 μg/ml) 非常有效
产品资料
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