产品
编 号：F045769
分子式：C18H11ClN2O
分子量：306.75
分子式：C18H11ClN2O
分子量：306.75
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CAS No: 114719-57-2
产品详情
生物活性：
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.
体内研究：
Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo
体外研究：
Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs).Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity..Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.
体内研究：
Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo
体外研究：
Fascaplysin induces autophagy as a cytoprotective response via ROS and p8 in vascular endothelial cells (VECs).Fascaplysin targets metabolic activity of the prostate cancer cells, without disrupting cell membrane's integrity..Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.
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