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编 号：F406741
分子式：C38H56N4O4
分子量：632.88
分子式：C38H56N4O4
分子量：632.88
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CAS No: 616885-87-1
产品详情
生物活性：
Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).
体内研究：
Memoquin (7-15 mg/kg；口服，一次) 可挽救 scopolamine 诱导的遗忘模型的记忆缺陷。Memoquin (15 mg/kg；口服，每天 1 次，连续 2-6 天) 6 天处理可完全挽救 Aβ1-42 诱导的遗忘模型的记忆缺陷。Animal Model:Mice with scopolamine-induced amnesia
Dosage:7, 10 and 15 mg/kg
Administration:Oral administration; 7, 10 and 15 mg/kg, once
Result:Reversed the scopolamine-induced memory deficits and verified by a T-maze test. Rescueed episodic memory impairment at a dose of 15 mg/kg.
Animal Model:Mice with Aβ- induced amnesia
Dosage:15 mg/kg
Administration:Oral administration; 15 mg/kg, daily for 2, 4, and 6 days before behavioral testing
Result:Weekly alleviated the insult induced by Aβ1-42 for 2-4 days treatment and fully rescued with a 6-day treatment.
体外研究：
Memoquin 抑制 hAChE，hAChE 诱导的 Aβ(1-40) 聚集，Aβ(1-42) 自聚集和 BACE-1 的 IC50 值分别为 0.00155，28.3，5.93 和 0.108 μM。Memoquin 具有与 hAChE 结合的特性，Ki 值为 2.6 nM。
Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).
体内研究：
Memoquin (7-15 mg/kg；口服，一次) 可挽救 scopolamine 诱导的遗忘模型的记忆缺陷。Memoquin (15 mg/kg；口服，每天 1 次，连续 2-6 天) 6 天处理可完全挽救 Aβ1-42 诱导的遗忘模型的记忆缺陷。Animal Model:Mice with scopolamine-induced amnesia
Dosage:7, 10 and 15 mg/kg
Administration:Oral administration; 7, 10 and 15 mg/kg, once
Result:Reversed the scopolamine-induced memory deficits and verified by a T-maze test. Rescueed episodic memory impairment at a dose of 15 mg/kg.
Animal Model:Mice with Aβ- induced amnesia
Dosage:15 mg/kg
Administration:Oral administration; 15 mg/kg, daily for 2, 4, and 6 days before behavioral testing
Result:Weekly alleviated the insult induced by Aβ1-42 for 2-4 days treatment and fully rescued with a 6-day treatment.
体外研究：
Memoquin 抑制 hAChE，hAChE 诱导的 Aβ(1-40) 聚集，Aβ(1-42) 自聚集和 BACE-1 的 IC50 值分别为 0.00155，28.3，5.93 和 0.108 μM。Memoquin 具有与 hAChE 结合的特性，Ki 值为 2.6 nM。
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