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编 号：F406576
分子式：C18H23N9O4S3
分子量：525.63
分子式：C18H23N9O4S3
分子量：525.63
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CAS No: 61622-34-2
产品详情
生物活性：
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
体内研究：
Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys.Animal Model:Female CF1/b mice with P. mirabilis xenograft
Dosage:12.5, 25, 50, 100, 200, 400 and 800 mg/kg
Administration:Subcutaneous injection; twice a day, for 5 days
Result:Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.
体外研究：
Cefotiam (SCE-963; 0-6.25μg/mL; 8 h) has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849.Cefotiam (0-6.25μg/mL; 8 h) has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL.
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
体内研究：
Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys.Animal Model:Female CF1/b mice with P. mirabilis xenograft
Dosage:12.5, 25, 50, 100, 200, 400 and 800 mg/kg
Administration:Subcutaneous injection; twice a day, for 5 days
Result:Reduced or complete eradicated bacteria in the bladder walls and kidneys of mice sacrificed the day after treatment was terminated.
体外研究：
Cefotiam (SCE-963; 0-6.25μg/mL; 8 h) has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849.Cefotiam (0-6.25μg/mL; 8 h) has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL.
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