产品
编 号：F406397
分子式：C9H9Cl2N
分子量：202.08
分子式：C9H9Cl2N
分子量：202.08
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CAS No: 61563-24-4
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生物活性：
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease.
体内研究：
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats.Animal Model:Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats
Dosage:40 mg/kg
Administration:i.p.; once daily; 3 days
Result:Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats.Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease.
体内研究：
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SKF-64139) (i.p., 40 mg/kg, once daily, 3 days) has an important role in the regulation of blood pressure and changes in adrenal catecholamine levels in rats.Animal Model:Male spontaneously hypertensive (SHR) and their age-paired normotensive Wistar-Kyoto (WKY) rats
Dosage:40 mg/kg
Administration:i.p.; once daily; 3 days
Result:Caused a decrease in blood pressure in SHR rats but no effect on blood pressure in WKY rats.Caused a decrease in hypothalamic epinephrine (Epi) levels, norepinephrine (NE) levels and raised dopamine (DA) levels in both SHR and WKY rats.
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