产品
编 号：F045699
分子式：C18H17F3N2O2
分子量：350.34
分子式：C18H17F3N2O2
分子量：350.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1146963-51-0
产品详情
生物活性：
(E/Z)-J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z)-J147 can readily pass the blood brain barrier (BBB). (E/Z)-J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z)-J147 has potential for the treatment of Alzheimer’s disease (AD).
体内研究：
(E/Z)-J147 (通过添加 200 ppm (E/Z)-J147 制备的饮食；6 个月) 增强老年小鼠的记忆力和树突棘数量。 (E/Z)-J147 的半衰期 (t1/2) 是在血浆中 1.5 小时和大脑中 2.5 小时时计算的 (每次口服给药，单剂量,20 mg/kg)。Animal Model:24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls
Dosage:200 ppm
Administration:The diet was prepared by the addition of 200ppm; 6 months
Result:While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with (E/Z)-J147.
体外研究：
(E/Z)-J147 以剂量依赖性方式促进 HT22 和原代细胞存活 (EC50 值范围为 0.06-0.115 μM)。
(E/Z)-J147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. (E/Z)-J147 can readily pass the blood brain barrier (BBB). (E/Z)-J147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. (E/Z)-J147 has potential for the treatment of Alzheimer’s disease (AD).
体内研究：
(E/Z)-J147 (通过添加 200 ppm (E/Z)-J147 制备的饮食；6 个月) 增强老年小鼠的记忆力和树突棘数量。 (E/Z)-J147 的半衰期 (t1/2) 是在血浆中 1.5 小时和大脑中 2.5 小时时计算的 (每次口服给药，单剂量,20 mg/kg)。Animal Model:24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls
Dosage:200 ppm
Administration:The diet was prepared by the addition of 200ppm; 6 months
Result:While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with (E/Z)-J147.
体外研究：
(E/Z)-J147 以剂量依赖性方式促进 HT22 和原代细胞存活 (EC50 值范围为 0.06-0.115 μM)。
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