产品
编 号：F405078
分子式：C7H8N4O2
分子量：180.17
分子式：C7H8N4O2
分子量：180.17
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 611-59-6
产品详情
生物活性：
Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
体外研究：
When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH+neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH+neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH+ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase).
Paraxanthine, a caffeine metabolite, provides protection against Dopaminergic cell death via stimulation of Ryanodine Receptor Channels.
体外研究：
When Paraxanthine (PX) is applied to the cultures for a prolonged period, the number of TH+neurons is augmented in a dose-dependent manner. The effect of Paraxanthine, already significant at 100 μM, increases gradually and remains optimal between 800 and 1000 μM, at 10 DIV. Counts of TH+neurons performs at different stages of maturation of the cultures indicate that Paraxanthine most likely prevents DA cell loss. GDNF, a prototypical trophic factor for DA neurons, is only slightly more effective than 800 μM Paraxanthine in rescuing DA neurons after 10 and 16 DIV when used at an optimal concentration of 20 ng/mL. About 80% of caffeine is N3-demethylated to form Paraxanthine, Unlike Paraxanthine, caffeine is poorly effective in protecting DA neurons from death For example, at a concentration of 800 μM, caffeine produces only a modest 40% increase in the number of TH+ cells at 10 DIV, whereas the same concentration of Paraxanthine optimally promotes DA cell survival (169% increase).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备