产品
编 号：F404838
分子式：C16H11BrO5S
分子量：395.22
分子式：C16H11BrO5S
分子量：395.22
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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50mg
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100mg
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询价
结构图
CAS No: 610753-87-2
产品详情
生物活性：
KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.
体外研究：
KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance.KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels.KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells.KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV).
KIN101 is a potent RNA viral inhibitor with IC50s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.
体外研究：
KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance.KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels.KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells.KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV).
产品资料
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