产品
编 号：F404016
分子式：C11H12O3
分子量：192.21
分子式：C11H12O3
分子量：192.21
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
10mg
480
In-stock
25mg
920
In-stock
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 607-91-0
产品详情
生物活性：
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc.
体内研究：
Myristicin 在动物模型中，可抑制胃癌细胞的生长以及 EGFR/ERK 信号通路。Myristicin (200 mg/kg; po; 单剂量) 提前 6 h 处理，对乙酸（AA）诱导的小鼠实验性结肠炎模型具预防和保护作用。Animal Model:Experimental colitis model in mice
Dosage:200 mg/kg
Administration: po; single dose, 6 h before Rectal AA (colitis inducer) instillation
Result: Reduced cellular oxidative stress induced by AA, and relieved the histopathological colonic damage, alleviated inflammation in the AA-induced colitis.
体外研究：
Myristicin (7.8-31.25 μM; 48 h) 可延缓胃癌细胞的增殖并诱导内质网 (ER) 应激和细胞凋亡；同时, Myristicin 降低细胞周期蛋白的表达，增加 Bax 的表达，激活半胱天冬酶，并增强细胞色素 C 的释放和线粒体 ROS 的水平。
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc.
体内研究：
Myristicin 在动物模型中，可抑制胃癌细胞的生长以及 EGFR/ERK 信号通路。Myristicin (200 mg/kg; po; 单剂量) 提前 6 h 处理，对乙酸（AA）诱导的小鼠实验性结肠炎模型具预防和保护作用。Animal Model:Experimental colitis model in mice
Dosage:200 mg/kg
Administration: po; single dose, 6 h before Rectal AA (colitis inducer) instillation
Result: Reduced cellular oxidative stress induced by AA, and relieved the histopathological colonic damage, alleviated inflammation in the AA-induced colitis.
体外研究：
Myristicin (7.8-31.25 μM; 48 h) 可延缓胃癌细胞的增殖并诱导内质网 (ER) 应激和细胞凋亡；同时, Myristicin 降低细胞周期蛋白的表达，增加 Bax 的表达，激活半胱天冬酶，并增强细胞色素 C 的释放和线粒体 ROS 的水平。
产品资料
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