产品
编 号：F404014
分子式：C28H41Cl3N4O2
分子量：572.01
分子式：C28H41Cl3N4O2
分子量：572.01
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CAS No: 60789-62-0
产品详情
生物活性：
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.
体内研究：
Clocapramine shows the lowest potency for D2-occupancy in vivo. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2).
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.
体内研究：
Clocapramine shows the lowest potency for D2-occupancy in vivo. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2).
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