产品
编 号：F404005
分子式：C39H61N11O12S2
分子量：940.1
分子式：C39H61N11O12S2
分子量：940.1
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
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询价
25mg
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询价
50mg
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结构图
CAS No: 60786-59-6
产品详情
生物活性：
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. .
体内研究：
(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice.(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats.Animal Model:Swiss Webster mice
Dosage:1 μM
Administration:Intratracheal administration for 24 h
Result:Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
体外研究：
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons.(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons.(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells.(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels.
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. .
体内研究：
(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice.(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats.Animal Model:Swiss Webster mice
Dosage:1 μM
Administration:Intratracheal administration for 24 h
Result:Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
体外研究：
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons.(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons.(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells.(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels.
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