产品
编 号：F403652
分子式：C21H27N7Na2O14P2
分子量：709.4
分子式：C21H27N7Na2O14P2
分子量：709.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
320
In-stock
500mg
480
In-stock
1g
792
In-stock
结构图
CAS No: 606-68-8
产品详情
生物活性：
NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.
体内研究：
NADH disodium salt (5 μMol/mouse；腹腔注射；once) 增加小鼠体内烟酰胺及其代谢物的尿排泄。 NADH disodium salt (500 mg/kg；ig；once) 促进酒精代谢并预防或改善乙醇负荷小鼠急性酒精暴露引起的早期肝损伤。 NADH disodium salt (1000 mg/kg；腹腔注射；一次) 增强组织 NAD+雄性 C57BL/6J 小鼠的水平。Animal Model:Male ICR mice
Dosage:5 μmol/mouse
Administration:Intraperitoneal injection or oral administration, once
Result:Produced significant increases in urinary excretions of nicotinamide (Nam) with intraperitoneal injection. Oral administration did not produce any increases in Nam or its metabolites.
Animal Model:Male C57BL/6J mice
Dosage:500 mg/kg
Administration:Intragastric administration, 15 min before ethanol administration
Result:Significantly increased blood acetaldehyde levels in mice administered with alcohol between 30 min and two hours. Significantly reduced the acetaldehyde in the blood after two hours. Inhibited the decrease of NAD+/NADH redox ratio in hepatocytes.
体外研究：
NADH disodium salt 在酸性条件下不稳定，但在碱性条件下稳定。 NADH disodium salt (0-1 mM；0-12 h) 增加 NAD+ 在各种哺乳动物细胞系中的水平。 NADH disodium salt (1 mM；24 小时) 具有低毒性并保护细胞免受遗传毒性。
NADH disodium salt (Disodium NADH) is an orally active reduced coenzyme. NADH disodium salt is a donor of ADP-ribose units in ADP-ribosylaton reactions and a precursor of cyclic ADP-ribose. NADH disodium salt plays a role as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation and the tricarboxylic acid (TCA) cycle.
体内研究：
NADH disodium salt (5 μMol/mouse；腹腔注射；once) 增加小鼠体内烟酰胺及其代谢物的尿排泄。 NADH disodium salt (500 mg/kg；ig；once) 促进酒精代谢并预防或改善乙醇负荷小鼠急性酒精暴露引起的早期肝损伤。 NADH disodium salt (1000 mg/kg；腹腔注射；一次) 增强组织 NAD+雄性 C57BL/6J 小鼠的水平。Animal Model:Male ICR mice
Dosage:5 μmol/mouse
Administration:Intraperitoneal injection or oral administration, once
Result:Produced significant increases in urinary excretions of nicotinamide (Nam) with intraperitoneal injection. Oral administration did not produce any increases in Nam or its metabolites.
Animal Model:Male C57BL/6J mice
Dosage:500 mg/kg
Administration:Intragastric administration, 15 min before ethanol administration
Result:Significantly increased blood acetaldehyde levels in mice administered with alcohol between 30 min and two hours. Significantly reduced the acetaldehyde in the blood after two hours. Inhibited the decrease of NAD+/NADH redox ratio in hepatocytes.
体外研究：
NADH disodium salt 在酸性条件下不稳定，但在碱性条件下稳定。 NADH disodium salt (0-1 mM；0-12 h) 增加 NAD+ 在各种哺乳动物细胞系中的水平。 NADH disodium salt (1 mM；24 小时) 具有低毒性并保护细胞免受遗传毒性。
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