产品
编 号:F402949
分子式:C26H44NNaO5S
分子量:505.69
产品类型
结构图
CAS No: 6042-32-6
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产品详情
生物活性:
Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist.
体内研究:
Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets.
体外研究:
Taurolithocholic acid (TLCA) at low concentrations (5 μM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%.TLCA (10 μM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms.