产品
编 号：F402708
分子式：C23H31NO7S
分子量：465.56
分子式：C23H31NO7S
分子量：465.56
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CAS No: 60325-46-4
产品详情
生物活性：
Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery.
体内研究：
Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min?kg, a Vss of 0.583 L/kg and an AUC of 149 ng?h/mL. Animal Model:Male cynomolgus monkey
Dosage:0.5 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a T1/2 of 0.451 hours, a CL of 56 mL/min?kg, a Vss of 0.583 L/kg and an AUC of 149 ng?h/mL.
体外研究：
Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells. Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs.
Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery.
体内研究：
Sulprostone (SHB 286; 0.5 mg/kg; IV) has a T1/2 of 0.451 hours, a CL of 56 mL/min?kg, a Vss of 0.583 L/kg and an AUC of 149 ng?h/mL. Animal Model:Male cynomolgus monkey
Dosage:0.5 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a T1/2 of 0.451 hours, a CL of 56 mL/min?kg, a Vss of 0.583 L/kg and an AUC of 149 ng?h/mL.
体外研究：
Sulprostone (SHB 286) has Ki values of 21 nM and 0.6 nM for EP1 and EP3 in cultured Chinese hamster ovary cells. Sulprostone (1, 1.5 or 2 mg/mL) does not significantly modify the viability and the purity of Dendritic cells (DCs). Sulprostone impairs spontaneous and directed DC migration independently from its concentration. Sulprostone reduces the expression of CCR7 and impairs migration of DCs.
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