产品
编 号：F402646
分子式：C7H16ClNO2
分子量：181.66
分子式：C7H16ClNO2
分子量：181.66
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
1g
480
In-stock
5g
720
In-stock
结构图
CAS No: 60-31-1
产品详情
生物活性：
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.
体内研究：
Acetylcholine chloride (ACh chloride；SC；20 mg/kg；单剂量) 在实验性感染中诱导显著的胆碱能刺激和小鼠存活率的增加。Animal Model:Male and female out-bred albino mice weighing 18-22 g (sepsis)
Dosage:20 mg/kg
Administration:SC; single dose
Result:Significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×109 E. coli bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.
体外研究：
乙酰胆碱氯化物 (ACh chloride；10 μM) 打开钙通道，在高钙培养基中荧光值和细胞内游离钙显著增加，而在无钙培养基中汗腺上皮细胞荧光值和细胞内游离钙降低。
Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro.
体内研究：
Acetylcholine chloride (ACh chloride；SC；20 mg/kg；单剂量) 在实验性感染中诱导显著的胆碱能刺激和小鼠存活率的增加。Animal Model:Male and female out-bred albino mice weighing 18-22 g (sepsis)
Dosage:20 mg/kg
Administration:SC; single dose
Result:Significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×109 E. coli bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.
体外研究：
乙酰胆碱氯化物 (ACh chloride；10 μM) 打开钙通道，在高钙培养基中荧光值和细胞内游离钙显著增加，而在无钙培养基中汗腺上皮细胞荧光值和细胞内游离钙降低。
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