产品
编 号：F402135
分子式：C9H17NO2
分子量：171.24
分子式：C9H17NO2
分子量：171.24
产品类型
规格
价格
是否有货
5mg
192
In-stock
10mg
296
In-stock
50mg
548
In-stock
100mg
920
In-stock
结构图
CAS No: 60142-96-3
产品详情
生物活性：
Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.
体内研究：
Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks.?Gabapentin (1-100 mg/kg; i.p.; once; male mice) has analgesic effect and reduces writhing in a dose-dependent manner.Animal Model:Male BALB/c mice (35-45 g)
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once
Result:Increased the time spent in target quadrant and decreased the distance to platform in MWM test.Decreased the transfer latency on second day in mEPM test.Prolonged retention latency in PA test.
Animal Model:Male mice (26-30 g)
Dosage:1, 5, 10, 50 and 100 mg/kg
Administration:Intraperitoneal injection; once
Result:Produced 45-70% inhibition of writhing.
体外研究：
Gabapentin (0-300 μM) produces a concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14?μM; maximal inhibition by 36%).?Gabapentin (100? μM) decreases the K+-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively.?Gabapentin (0-1000 μM) reduces the K+-evoked [3H]-noradrenaline release in neocortical slices (IC50=48?μM; maximal inhibition of 46%) but not from synaptosomes.
Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.
体内研究：
Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks.?Gabapentin (1-100 mg/kg; i.p.; once; male mice) has analgesic effect and reduces writhing in a dose-dependent manner.Animal Model:Male BALB/c mice (35-45 g)
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once
Result:Increased the time spent in target quadrant and decreased the distance to platform in MWM test.Decreased the transfer latency on second day in mEPM test.Prolonged retention latency in PA test.
Animal Model:Male mice (26-30 g)
Dosage:1, 5, 10, 50 and 100 mg/kg
Administration:Intraperitoneal injection; once
Result:Produced 45-70% inhibition of writhing.
体外研究：
Gabapentin (0-300 μM) produces a concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14?μM; maximal inhibition by 36%).?Gabapentin (100? μM) decreases the K+-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively.?Gabapentin (0-1000 μM) reduces the K+-evoked [3H]-noradrenaline release in neocortical slices (IC50=48?μM; maximal inhibition of 46%) but not from synaptosomes.
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