产品
编 号：F400905
分子式：C12H13N3O3S
分子量：279.31
分子式：C12H13N3O3S
分子量：279.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 59729-37-2
产品详情
生物活性：
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei.
体内研究：
Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities. Animal Model:Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesiense
Dosage:20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO)
Administration:IP or PO; daily; four consecutive days
Result:Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.
体外研究：
Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei.
体内研究：
Fexinidazole (HOE 239; 20-50 mg/kg/day of IP or 25-100 mg/kg/day of PO; four consecutive days) has antitrypanosomal activities. Animal Model:Adult female NMRI mice weighing between 20 and 25 g T. b. rhodesiense
Dosage:20, 50 mg/kg (IP) or 25, 50, 100 mg/kg (PO)
Administration:IP or PO; daily; four consecutive days
Result:Had antitrypanosomal activities, with 100 mg/kg/day p.o. being 100% curative.
体外研究：
Fexinidazole (HOE 239) has two principal metabolites, sulfoxide and sulfone. They have shown trypanocidal activity in vitro with IC50s of 0.7-3.3 μM (0.2-0.9 μg/ml) range against all parasite strains tested.
产品资料
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