产品
编 号：F005058
分子式：C18H13ClF4N2O3
分子量：416.75
分子式：C18H13ClF4N2O3
分子量：416.75
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1010396-29-8
产品详情
生物活性：
S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
体内研究：
By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively.Animal Model:Male Sprague Dawley rats (in castrated male rats)
Dosage:0.01-3 mg
Administration:S.c.; daily for 14 d
Result:Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.
体外研究：
S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM.
S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
体内研究：
By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively.Animal Model:Male Sprague Dawley rats (in castrated male rats)
Dosage:0.01-3 mg
Administration:S.c.; daily for 14 d
Result:Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.
体外研究：
S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM.
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