产品
编 号:F400725
分子式:C6H5NO2
分子量:123.11
产品类型
结构图
CAS No: 59-67-6
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产品详情
生物活性:
Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases.
体内研究:
Niacin (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice.Animal Model:Male C57BL/6 mice
Dosage:3-300 mg/kg
Administration:Subcutaneous injection; once
Result:Induced vasodilation in a dose-dependent manner.
体外研究:
Niacin (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism.Niacin (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation.