产品
编 号：F400616
分子式：C12H13N3O2
分子量：231.25
分子式：C12H13N3O2
分子量：231.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 59-63-2
产品详情
生物活性：
Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro.
体内研究：
Isocarboxazid (1、3 mg/kg，腹腔注射，60 分钟) 预处理小鼠显示 5-HTP 后 15 分钟和 30 分钟的头部抽搐次数显著增加。 Isocarboxazid (1，3 mg/kg，ip，60 分钟) 与 5-HTP 给药一起处理小鼠导致 43% 的 5-HT 浓度增加，与单独给予 5-HTP 的小鼠大脑浓度相比，5-HIAA 减少 22%。Animal Model:Twelve male mice of dd strain (20-25 g)
Dosage:0, 0.3,1, 3 mg/kg
Administration:Intraperitoneally 60 min before intravenous injection of 5-HTP
Result:The number of head twitches at 15 and 30 min after 5-HTP was increased.43% 5-HT concentration increased and 22% of 5-HIAA decreased.
Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro.
体内研究：
Isocarboxazid (1、3 mg/kg，腹腔注射，60 分钟) 预处理小鼠显示 5-HTP 后 15 分钟和 30 分钟的头部抽搐次数显著增加。 Isocarboxazid (1，3 mg/kg，ip，60 分钟) 与 5-HTP 给药一起处理小鼠导致 43% 的 5-HT 浓度增加，与单独给予 5-HTP 的小鼠大脑浓度相比，5-HIAA 减少 22%。Animal Model:Twelve male mice of dd strain (20-25 g)
Dosage:0, 0.3,1, 3 mg/kg
Administration:Intraperitoneally 60 min before intravenous injection of 5-HTP
Result:The number of head twitches at 15 and 30 min after 5-HTP was increased.43% 5-HT concentration increased and 22% of 5-HIAA decreased.
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