产品
编 号：F400349
分子式：C24H32O4
分子量：384.51
分子式：C24H32O4
分子量：384.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
询价
询价
5g
询价
询价
结构图
CAS No: 595-33-5
产品详情
生物活性：
Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.
体内研究：
Megestrol acetate (100 or 300 mg/kg, Subcutaneously daily over a 7-day period) is able to reduce the weight loss produced by both TNF and by the MAC16 tumour.Animal Model:Pure strain female NMRI mice (age 6 to 8 weeks).
Dosage:100 or 300 mg/kg (50 mg megestrol acetate was suspended in 3 ml of pure corn oil).
Administration:Subcutaneously daily over a 7-day period.
Result:Produced a highly significant reversal of the TNF-induced decrease in body weight, accompanied by a significant increase in both food and water intake.Caused an increase in body weight over a 24-hour period to female NMRI mice.No effect on blood glucose levels in saline controls, concurrent administration of megestrol acetate with TNF caused a significant increase in blood glucose compared with administration of TNF alone.Caused a dose-related reduction in the loss of host body weight in animals bearing the MAC16 tumour.
体外研究：
Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line.
Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway.
体内研究：
Megestrol acetate (100 or 300 mg/kg, Subcutaneously daily over a 7-day period) is able to reduce the weight loss produced by both TNF and by the MAC16 tumour.Animal Model:Pure strain female NMRI mice (age 6 to 8 weeks).
Dosage:100 or 300 mg/kg (50 mg megestrol acetate was suspended in 3 ml of pure corn oil).
Administration:Subcutaneously daily over a 7-day period.
Result:Produced a highly significant reversal of the TNF-induced decrease in body weight, accompanied by a significant increase in both food and water intake.Caused an increase in body weight over a 24-hour period to female NMRI mice.No effect on blood glucose levels in saline controls, concurrent administration of megestrol acetate with TNF caused a significant increase in blood glucose compared with administration of TNF alone.Caused a dose-related reduction in the loss of host body weight in animals bearing the MAC16 tumour.
体外研究：
Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line.
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