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编 号:F400181
分子式:C18H13ClFN3O
分子量:341.77
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1mg
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生物活性:
1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam.

体外研究:
1'-Hydroxymidazolam (5?nM-1?μM) induces a significant inhibition of the action potential firing rate at concentrations of 100?nM or higher and causes a steady increase in the depression of network activity with increasing concentrations of up to 1?μM in neocortical slice cultures from wild-type mice.
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