产品
编 号:F400181
分子式:C18H13ClFN3O
分子量:341.77
产品类型
结构图
CAS No: 59468-90-5
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产品详情
生物活性:
1'-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1'-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam.
体外研究:
1'-Hydroxymidazolam (5?nM-1?μM) induces a significant inhibition of the action potential firing rate at concentrations of 100?nM or higher and causes a steady increase in the depression of network activity with increasing concentrations of up to 1?μM in neocortical slice cultures from wild-type mice.