产品
编 号：F400120
分子式：C58H72CaN6O12
分子量：1085.3
分子式：C58H72CaN6O12
分子量：1085.3
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CAS No: 59450-89-4
产品详情
生物活性：
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.
体内研究：
Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage.Animal Model:Mice (ICR, 25-30 g)
Dosage:2.5 or 7.5 nM
Administration:Intrapleurally
Result:Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
体外研究：
Calcimycin hemicalcium salt (A-23187 calcium) mediatesmycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.
体内研究：
Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage.Animal Model:Mice (ICR, 25-30 g)
Dosage:2.5 or 7.5 nM
Administration:Intrapleurally
Result:Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
体外研究：
Calcimycin hemicalcium salt (A-23187 calcium) mediatesmycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
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