产品
编 号：F044900
分子式：C23H39NO4
分子量：393.56
分子式：C23H39NO4
分子量：393.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 114289-47-3
产品详情
生物活性：
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway.
体内研究：
PD 128042 (CI 976) (10-30 mg/kg；管饲，在慢性胆固醇喂养大鼠模型中) 降低非高密度脂蛋白 (HDL)-胆固醇并增加预先建立的血脂异常大鼠的 HDL-胆固醇。
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway.
体内研究：
PD 128042 (CI 976) (10-30 mg/kg；管饲，在慢性胆固醇喂养大鼠模型中) 降低非高密度脂蛋白 (HDL)-胆固醇并增加预先建立的血脂异常大鼠的 HDL-胆固醇。
产品资料
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