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编 号：F399990
分子式：C20H22N8O6
分子量：470.44
分子式：C20H22N8O6
分子量：470.44
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CAS No: 5939-37-7
产品详情
生物活性：
7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
体内研究：
7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.Animal Model:Male Wistar rats (270-440 g)
Dosage:4 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.
体外研究：
7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) .
7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
体内研究：
7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.Animal Model:Male Wistar rats (270-440 g)
Dosage:4 mg/kg (Pharmacokinetic Analysis)
Administration:IV
Result:Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.
体外研究：
7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) .
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