产品
编 号：F397922
分子式：C17H21NO
分子量：255.35
分子式：C17H21NO
分子量：255.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
250mg
360
In-stock
结构图
CAS No: 58-73-1
产品详情
生物活性：
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .
体内研究：
Diphenhydramine (0-10 mg/kg, i.v. and p.o.) 与茶苯海明 Dimenhydrinate (HY-B1215) 联合使用时，口服生物利用度更好。Diphenhydramine (20 mg/kg, i.p.) 可改善顺铂Cisplatin (CDDP) (HY-17394) 对小鼠引起的肾损伤，同时不会影响到顺铂的抗肿瘤效果。药代动力学分析RouteDose (mg/kg)AUClast (ng·h/mL)C0 (ng/Ml)CL (Ml/h/kg)T1/2 (h)Kel (1/h)MRT (h)Vss_obs (mL/kg)Cmax (ng/mL)Tmax (h)Vz (mL/kg)F (%)
i.v.5391.20266.102833.041.890.452.476582.36////
p.o.5153.80//4.980.596.97/35.801.30180157.367.75
Animal Model:healthy, fasted mixed-breed dogs
Dosage:1/5/10 mg/kg
Administration:i.v., p.o.
Result:Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product Dimenhydrinate (HY-B1215).
体外研究：
Diphenhydramine (1-300 μM, 30 s) 可阻断 NMDA 激活的膜电流，这一特性可负责或增加其镇静、镇痛和记忆相关的作用。
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .
体内研究：
Diphenhydramine (0-10 mg/kg, i.v. and p.o.) 与茶苯海明 Dimenhydrinate (HY-B1215) 联合使用时，口服生物利用度更好。Diphenhydramine (20 mg/kg, i.p.) 可改善顺铂Cisplatin (CDDP) (HY-17394) 对小鼠引起的肾损伤，同时不会影响到顺铂的抗肿瘤效果。药代动力学分析RouteDose (mg/kg)AUClast (ng·h/mL)C0 (ng/Ml)CL (Ml/h/kg)T1/2 (h)Kel (1/h)MRT (h)Vss_obs (mL/kg)Cmax (ng/mL)Tmax (h)Vz (mL/kg)F (%)
i.v.5391.20266.102833.041.890.452.476582.36////
p.o.5153.80//4.980.596.97/35.801.30180157.367.75
Animal Model:healthy, fasted mixed-breed dogs
Dosage:1/5/10 mg/kg
Administration:i.v., p.o.
Result:Oral absorption of diphenhydramine was approximately three times greater with a longer half-life when it was administered as the combination product Dimenhydrinate (HY-B1215).
体外研究：
Diphenhydramine (1-300 μM, 30 s) 可阻断 NMDA 激活的膜电流，这一特性可负责或增加其镇静、镇痛和记忆相关的作用。
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