产品
编 号：F397769
分子式：C16H12ClN3O3
分子量：329.74
分子式：C16H12ClN3O3
分子量：329.74
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 58662-84-3
产品详情
生物活性：
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect. Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect.
体内研究：
Meclonazepam (0.1-5.6 mg/kg) exhibits anxiolytic effect in gerbils.Meclonazepam (40 and 80 mg/kg) Has highly significant effect on the immature schistosomes.Animal Model:Adult experimentally naive male Mongolian gerbils (Meriones unguiculatus)
Dosage:0.1, 0.3, 1.0, 3.0, 5.6 mg/kg
Administration:Administration intraperitoneally (IP) 5 min prior to training onset.
Result:The ED50 of 0.77-0.78 mg/kg at the 5 min post-injection (p.i.).
Animal Model:CB6F1 mice were infected with single-sex male S. mansoni cercariae 28 days before treatment
Dosage:40 and 80 mg/kg
Administration:Administered by gavage either as single drugs or in a sequence consisting of 1 dose of Praziquantel (PZQ), a 5-min interval, 1 dose of Ro, a 15-min interval, a second dose of PZQ.
Result:PZQ had no significant effect on the immature schistosomes, whereas Ro 11-3128 was highly effective.
体外研究：
Meclonazepam causes initially a massive spastic paralysis of immature S. mansoni.
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect. Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect.
体内研究：
Meclonazepam (0.1-5.6 mg/kg) exhibits anxiolytic effect in gerbils.Meclonazepam (40 and 80 mg/kg) Has highly significant effect on the immature schistosomes.Animal Model:Adult experimentally naive male Mongolian gerbils (Meriones unguiculatus)
Dosage:0.1, 0.3, 1.0, 3.0, 5.6 mg/kg
Administration:Administration intraperitoneally (IP) 5 min prior to training onset.
Result:The ED50 of 0.77-0.78 mg/kg at the 5 min post-injection (p.i.).
Animal Model:CB6F1 mice were infected with single-sex male S. mansoni cercariae 28 days before treatment
Dosage:40 and 80 mg/kg
Administration:Administered by gavage either as single drugs or in a sequence consisting of 1 dose of Praziquantel (PZQ), a 5-min interval, 1 dose of Ro, a 15-min interval, a second dose of PZQ.
Result:PZQ had no significant effect on the immature schistosomes, whereas Ro 11-3128 was highly effective.
体外研究：
Meclonazepam causes initially a massive spastic paralysis of immature S. mansoni.
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